More help and monitoring might be essential when prescribing for people vulnerable to opioid misuse.Keep an eye on Carefully (one)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Mitotane is a powerful inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrate